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SEASON TWO
Raindrops Keep Falling On My Head
Derek's wife Addison sticks around Seattle Grace to work on a high profile fetal surgery case. Joe, the friendly bartender across the street needs a major surgery, drumming up sympathy from everyone in the hospital -- including Alex. Izzie sees this softer side of Alex. George is assigned "sponge duty" for the still-recovering Richard (brain surgery in 108). Burke wants to go on an actual date with Cristina, but she's got other things on her mind. Meredith has to work with her boyfriend's wife...

Enough is Enough
As interim chief, Burke gets a little abuse from his fellow surgeons: It's lonely at the top. Derek and Burke are jealous of each other and competitive, but when push comes to shove, Burke defends Derek, showing him respect as a fellow surgeon. Meanwhile, Richard is not a very good patient. We meet Richard's wife, Adele, who was on vacation. Richard had brain surgery and didn't tell his own wife. An abusive father/husband needs a liver, which Cristina doesn't believe he deserves.
The son is a potential donor (has a choice to donate part of his liver), and Alex relates to him because Alex's father was also abusive. Bailey and Meredith's patient swallowed 10 Judy doll heads. Bailey needs all the interns to help her dissect the doll heads from the patient's bowels. Meredith relates to the patient when he says he feels empty. Meredith still feels betrayed by Derek, and feels empty, like "a sink with an open drain." George's transplant donor is not brain dead as anticipated. She has a tumor on her brain stem, which Derek operates.

Make Me Lose Control
Ellis is admitted to the hospital. The secret is out -- Meredith's mom, the brilliant surgeon, has Alzheimer's. Cristina faints in Burke's surgery. Addison operates on Cristina who loses the baby and one of her fallopian tubes. Bailey is supportive of Cristina through her surgery and recovery. Burke is concerned for Cristina, but is kept busy in surgery. He finally discovers Cristina was pregnant. The interns sit at Cristina's bedside, after her surgery, but Burke can't bring himself to enter. Izzie and Alex are flirting with each other. Izzie feels left out, always the last to know about everything -- especially when it comes to her friends. George reminds Ellis of Meredith's father. He defends Meredith to Ellis: I don't like the way you talk to her. Then later, he comforts Ellis by lying in bed with her, letting her think he's Thatcher.
Female patients find Derek just as McDreamy as the staff -- as is the case with Derek's young patient who is in for surgery to make her stop blushing. Addison asks Derek to consult on a case of a premature baby in ICU, who has very little chance of surviving. Addison has hope, both for the baby, and for their marriage. She kisses Derek. Richard comes back to the hospital before Derek clears him for surgery. Derek is holding a grudge because Richard gave interim chief to Burke and invited Addison "Satan" to Seattle. Meredith tells Richard that Ellis is reliving the heyday of her residency and would appreciate a visit from him. Richard can't bring himself to go see Ellis. He tells George to take care of her. When Richard finally goes to Ellis' room, Ellis grabs Richard's hand: Richard, you beautiful man, thank God you're here. Meredith finally breaks down from having to pretend all day long that she is fine. She is tired of hating Derek. She can't do it anymore. Meredith kisses Derek.

Deny Deny Deny
There's hope for Meredith and Derek. Derek says Addison is leaving. He shows Meredith the divorce papers that Addison gave him to sign. Meredith's mother is still in the hospital but keeps escaping from her room, thinking she's still a doctor. Meredith wonders/fears if she's anything like her mother. Richard depends on George to watch out for Ellis. One of Bailey's very first patients -- one with Cystic Fibrosis -- returns to the hospital. Bailey is very attached emotionally to this patient and has a tough time when he dies in surgery. Cristina is a terrible patient. She steals charts from nurse's station and rounds with the other interns until Bailey sends her back to her room. Cristina's mother is the antithesis of Cristina. When Burke gets Cristina alone, he says he had a right to know about the pregnancy. Alex asks Izzie out on a date. Alex didn't pass the clinical skills portion of his medical boards. He has four months to take it again and pass or he's out. Izzie and Alex meet at Joe's to go on their first date, but Alex is in a foul mood.
Ellis kisses Richard. George does what Richard can't bring himself to do  he restrains Ellis' wrists to the hospital bed. Finally, Cristina completely breaks down and can't stop crying: "Someone please sedate me!" Burke gets into Cristina's bed, comforting her. Addison puts on her wedding ring in front of Meredith: She's not leaving Seattle if there's the slightest chance Derek wants her back. At the end of the day, Meredith sees the divorce papers -- unsigned -- in Derek's bag.

Bring the Pain
A power failure cripples Seattle Grace Hospital, trapping Alex and George in an elevator with a gunshot wound victim desperately in need of heart surgery. Alex freezes, but George is able to do what needs to be done. Burke talks George through the operation from outside the elevator's door. Meanwhile Cristina is forced to relieve the pain of a unique patient for whom pain medicine is out of the question. He had been using video porn to relieve his pain (not a perv  it really was the only pain management he could take), and now without the power, Cristina has to paint the same pictures with her words.
Meredith and Derek treat a Hmung patient who needs to "find her soul" before they can operate. Izzie deals with a female patient who literally has a broken heart  she experiences what appears to be a heart attack every year on the anniversary of an old lover's death. Richard and Meredith say good-bye to Ellis, who is checking out of the hospital, and Meredith finally makes a move back to Derek, pleading for him to "pick me, choose me." She goes to the bar across the street to wait for his response.

Into You Like A Train
Meredith waits at the bar for Derek, but before he arrives, a train wreck calls all the interns back to the hospital. Alex, still reeling from his embarrassing moment in the elevator, is forced to watch a couple train victims -- one of whom is in bad shape, the other not. And it's the one who's not -- the one that no one pays any attention to -- that winds up dying. Cristina is assigned by Richard to find the severed leg of a victim, which is more difficult than it should be -- and her boyfriend Burke is of no help. Izzie and Addison treat a pregnant victim who is very badly burned. They are able to deliver the baby, but with her arms badly burned, the only way she can feel her baby is to have the baby held up to face. Meredith, unfortunately, starts off too drunk to do anything.
Bailey keeps her from practicing medicine until she's sober, and which point and she and George are both helping Burke, Bailey and Derek on the giant case of the day: two strangers impaled on the same pole, both fully conscious, and the pole is the only thing keeping them both alive. The removal surgery is so tricky, only one patient is likely to make it out alive, and they have to choose. Meredith finds out that Derek chose Addison as this story unfolds. And Derek is reeling, too -- so drained from his decision and having to face Meredith, he breaks down in the elevator, with Bailey.

Something To Talk About
Gossip is all the rage at SGH, with Meredith feeling the brunt it. And, medically, one case has peaked the curiosity of the doctors -- a man who presents as pregnant. Even his home pregnancy test is positive. Izzie and Cristina try to steal this case from psych to cheer Meredith up. As the patient becomes as much as a hospital fascination as her love life, Meredith begins to sympathize with him, and eventually kicks everyone out of his room to give the patient his privacy. Burke wants to come clean to the chief about his relationship with Cristina, but Cristina disagrees. When Cristina starts getting a ton of crappy scut assignments -- she assumes Bailey has figured things about between her and Burke and this is her punishment& Bailey doesn't know, though. Izzie is pissed at Alex for being so emotionally withdrawn from her all of a sudden -- he wins her over at the end -- when he finally kisses her quite publicly and quite spectacularly.
George is still "Burke's guy" after his elevator heroics -- and he works with Burke on a female heart patient who shouldn't be alive. She's had several heart surgeries over the last few years, and no one is more surprised that she's still around than her battered husband. During this surgery, the woman's heart actually catches on fire, but Burke saves her, and she lives to batter her husband another day& Which prompts him to finally leave her. Derek -- after couples' counseling with Addison  works with Alex on a paralyzed girl who is a candidate for a procedure that can ease her life. Her overprotecting mother won't let her have the procedure, but Derek and Alex know it's the best thing, so it's up to Alex to somehow convince the girl to want the procedure for herself. Richard offers Addison a full time position at SGH.

Let It Be
Friends of Derek and Addison's from NY come to Seattle but not for a social visit. The wife would like a preventative hysterectomy and mastectomy because she just discovered she has a gene that makes her susceptible to cancer in those regions. The wife wants the surgery, the husband thinks she's going too far, and the doctors -- including Izzie who's on the case -- are all in between. George nearly gets trampled by a window washer who falls from a high window.
The man survives because he lands on a pigeon, and is taken to the hospital. George thinks it's a miracle this guy survived, but the guy has a different take on things. Meredith and Bailey work with a couple where the wife finds out she has only a few months to live. She asks them not to tell her husband, but they already have -- and when told the news, the husband asks them not to tell the wife. They both want to protect the other from the news. Cristina and Burke go on a date, but it's not going so swimmingly at all -- until the date turns into a case when a fellow patron at the restaurant needs medical attention. It turns out to be the best date ever.

Thanks For the Memories
Meredith, Bailey, Derek, and Richard -- each for their own reasons -- decide to work on Thanksgiving while everyone else takes the day off. Izzie cooks a spectacular Thanksgiving dinner for everyone -- except that no one really shows up. After Cristina bails to head back to the hospital to help with some holiday related surgeries, Izzie and Burke wind up preparing the dinner by themselves for Joe and his boyfriend. George is spending the day with his blue collar brothers & father, working through major issues with them.
The hunting trip is not without incident, though, the father does get accidentally shot in the butt, so George winds up back at the hospital as well, where he runs into Meredith and Cristina. Meredith has been working all day with Derek on the case of a coma patient that is able to be revived after many, many years. His family had already moved on, and it's not as good of news as Meredith and Derek would've hoped. And they have even worse news yet for the patient -- he's a medical miracle that they were able to revive him, but he's got a bad brain aneurisym that could still kill him at any moment. Meredith finds Alex in the hospital, too, and he confides in her that he's studying to retake his medical boards. Meredith has a nice moment of semi-closure with Derek over Addison before heading home with Alex for Thanksgiving dinner, but Meredith doesn't go in. She goes back to the bar, where she seems open to the idea of meeting a new guy. She lets a guy buy her a drink, but only after finding out that he's not a doctor.

Much Too Much
Meredith tries to dismiss a one-night-stand from her house much like she did Derek many months earlier -- and like Derek, she's surprised to find the guy at the hospital later that day. Unlike Derek, he's not a doctor  but a patient. He has an erection that won't quit, and actual requires medical attention from Meredith, Cristina, and Bailey. For all intents and purposes, it looks to them like Meredith broke the man's penis. And when the cause of the "priaprism" cannot be diagnosed, they have no choice but to call in for a neurological consult -- from Derek himself. Cristina wakes up to find that Burke has "keyed" her. He not only wants her to have a key to his apartment, he actually would like for her to move in with him. Cristina has issues with this, and she takes Burke to her apartment to show him just how bad of an idea that really is -- Cristina is the single messiest person in the world.
Alex begins the episode unable to perform with Izzie. A sense of failure hangs over him. Medically, he's assigned to work with Derek on a man with a tumor that's causing him to drink too much water. Dangerously too much water. The man has a sodium imbalance caused by the excess of water, but when Alex gives the wrong order to Nurse Olivia when trying to compensate for that imbalance, he leaves the patient on the verge of death. This is too much for Alex, and in a moment of weakness he and Olivia wind up rekindling their faded relationship -- and they are in the throes of passion when Izzie finds him. Izzie and George have been assigned to work with Burke and Addison on the quints about to be born. The mother took fertility drugs, to try to have just one daughter -- and now she has five babies on the way that will all need surgical attention soon after birth. That is disconcerting to Izzie, who wonders why anyone would put her children in such a position voluntarily, especially when the mother had the option to reduce the number of births. But the mother explains it to her quite succinctly: how in the world could she choose, of the five, which ones would be born and which ones wouldn't? The episode ends with all the interns rallying around the mother and her babies as Addison leads her through the complicated birthing.

Owner of a Lonely Heart
Cristina has little sympathy for Constance Ferguson, a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches a boiling point, and Addison decides to teach Izzie a very painful lesson.

Grandma Got Run Over By a Reindeer
A young boy needs a heart transplant but doesn't seem to want it, and an argument over his treatment exposes major philosophical differences between Burke and Cristina -- he's spiritual, she's not. Burke won't operate on the boy until his mind accepts the heart, because he believes the body will reject it if he doesn't. Cristina, though not a believer, makes a connection with the kid over their shared skepticism, and gets the boy to want the heart. Meanwhile, when the interns rally to help Alex prepare to re-take his exam, Izzie feels betrayed (after all, Alex just cheated on her). Meredith has to remind Izzie of the true spirit of the Christmas holiday.
Derek and Izzie treat a father who has a major attitude change after brain surgery -- the family thinks that Derek may have broken their dad, and Izzie doesn't necessarily disagree. George and Bailey deal with a woman needing minor surgery that keeps getting her surgery delayed. The woman's family is loud, obnoxious, and crazy, and George has to really stand up to them at the end. As for Derek, despite a reconciliation with Addison, Derek isn't in a festive mood. Christmas is about being with the one you love, and he doesn't think he's with that person.

Begin the Begin
Richard enforces an 80hr rule for the interns -- 80hrs per week of work and that's it. Meredith is sent home for working too long of a shift. She does laundry and then goes to visit her mother at the nursing home -- where she finds Derek. Derek wants to help Ellis, but Meredith doesn't want his help. Derek needs Richard to intervene. Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient who's awaiting a heart transplant. Bailey goes to retrieve Denny's heart, taking Cristina along for the ride. Meanwhile George and Addison treat Bex, a young teen hermaphrodite. And the dog proves troublesome to all who dwell at Casa de Interns -- including Meredith, after he destroys her freshly washed laundry.

Tell Me Sweet Little Lies
Meredith is calling Derek "McDreamy" again as he helps her get her mother in a special clinical trial. Cristina reveals to Meredith that she hasn't really moved in with Burke  he only thinks she has. George tries to turf an elderly patient onto another service, to get her off the surgical floor a month after she actually had her surgery. Alex and Izzie deal with a competitive eater with a bad esophagus, but they have other things on their mind: Alex just got his medical exam results back, and Izzie wants Meredith to get rid her dog. George gives Meredith an ultimatum: "Either the dog goes, or I go." Meredith hesitates. Bailey suffers from some false (and distracting) labor pains that worry Addison. Oh, and the dog is at the hospital.

Break On Through
The nurses are on strike and everyone is suffering. Bailey is on bedrest, meaning the interns are being overseen by a new resident, Sydney -- the anti-Bailey. All the interns find a way to avoid this ever-chirpy cheerleader of a surgeon, except for Alex and Cristina, who wind up working with her on a case of flesh-eating bacteria on her leg. Alex and the resident try to save the patient's leg, where Cristina sees amputation as the only way to save the girl's life. She even goes to Burke for help, having his question the resident's methods in the OR while she operates on the leg. Cristina winds up wrong and Burke isn't very happy that he overstepped his bounds as a doctor because of his role as her boyfriend. Izzie on a case with Addison with a pregnant teenager who's baby needs an EXIT surgery -- a risky operation that requires half-delivering the baby before operating and then finishing the delivery. The girl, though, is not sure of her ability to be a mom so young, to which Izzie makes a startling revelation -- she had a daughter when she was 16 that she put up for adoption.
George doesn't have a case in this episode because he's siding with the nurses while they are on strike. George refuses to cross the picket line into the hospital until the nurses themselves talk George into going in there to at least check on their patients. Meredith saves a dying elderly patient who was DNR, but not properly labeled as such. Alive only in the loosest sense of the word, the patient's friends want Meredith to take out the tube keeping her alive. Meredith has end this life, which causes her to have a mini-breakdown in the closet at she thinks about her own mother's mortality (and that fact that she seems to be alone). Derek is there to comfort her. Though initially disapproving of the fact that Richard had been secretly visiting her mother, Meredith decides to let him continue doing it because he's like Ellis's lifeline that she doesn't want to pull out.

It's the End of the World
The episode begins with a dream of Izzie, Cristina, and George in the shower together. It's George's dream. Meredith refuses to go to work. She has this feeling that she will die. George and Izzie can't get her out of bed, they have to call in Cristina. Once at the hospital, the premonition seems to have some validity. A trauma victim is brought in by a paramedic with her hand still stuck inside him to stop the bleeding. As Alex soon discovers though, her hand isn't the only thing inside of him -- after trying to make a homemade bazooka, he's also got a piece of unexploded munitions inside of him. This places the hospital on Code Black, which essentially shuts down the surgical wing -- save for the one operation that has already begun: Derek and Cristina operating on the brain of a man who happens to be Bailey's husband.
Bailey's husband got into a car accident trying to get to the hospital on time because Bailey is now going into labor. Though the bomb squad, lead by Dylan Young, wants to clear out the ORs of all unnecessary personnel, Derek, Cristina, and Meredith all insist on staying (Meredith is with the paramedic, Hannah, who's got her hand in the patient). After a chat with George about being "doers versus watchers" (they feel Cristina and Meredith are the "doers"), Izzie decides to ignite things with Alex -- in the supply closet. Richard is trying his best to keep the hospital in some sort of order amidst the chaos, but he's having a tough time. In fact, things degrade quite quickly all around, most notably when an anesthesiologist leaves Hannah alone with the patient and the bomb while all the other doctors are strategizing with Dylan. Meredith finds Hannah having a nervous breakdown, about the pull her hand out and potentially put them all in danger (not to mention kill the patient who's bleeding she's suppressing). Hannah does pull her hand out and run away -- but not before Meredith can take her place as the girl with her hand in the explosive patient.

As We Know It
Without her husband by her side, Bailey refuses to have the baby. Addison strongly disagrees -- that baby has to come out, and Addison would much rather have Bailey's cooperation on this. George works with Addison to convince Bailey to have the baby, and it's George who finally gets through to her. Richard isn't doing so well, though, with the stress, and he suffers an anxiety attack that lures Adele to the hospital.
Burke and Meredith successfully remove the explosive device from the body and hand it off to Dylan, but not before Dylan has a bit of a spark with Meredith. Meredith goes out to say something to him -- anything, maybe just a "thank you" -- but she doesn't have a moment. The device explodes -- killing Dylan right in front of Meredith. Izzie and Cristina wind up in the shower with Meredith for real, cleaning Dylan bits off of her. Derek comes to visit Meredith at the house, to see how she's doing. There Meredith admits she can't even remember the last time they kissed. But Derek does. In excruciating detail. And then he goes.

Yesterday
Meredith and Burke treat a patient who probably won't survive surgery. The patient asks Meredith to videotape where he vents out to everything who's ever wronged him. Cristina and Alex work with Derek on the case of a teenager with Lionitis -- but his disfigured appearance doesn't keep him from flirting with Cristina. George and Izzie attend to a patient with Addison -- a woman suffering from spontaneous orgasms. Personally, Mark, Derek's best friend who slept with Addison, returns to convince Addison to come back to him. But he winds up moving in on Derek's case instead (when he's not hitting on Meredith). Burke finds out that Cristina didn't really move in with him -- she still has another apartment.
Izzie tries to keep from sleeping with Alex again -- but she can't. And George is about to explode stuffing his feelings for Meredith for long. Meredith wants to know more about why her dad left -- and winds up going directly to him to find out. After an emotionally trying day -- dealing with her mom, her dad, and everything in between -- she goes home, that's when George is finally ready to say everything to her that she needs to hear.

What Have I Done to Deserve This?
No one knows what transpired between George and Meredith but George and Meredith -- and they aren't talking, but everyone knows something happened. They suffer in silence over their transgression -- until everything bubbles to the surface, and once the secret is spilled, it's only a matter of minutes before George spills, too -- down a stairwell, where he dislocated his shoulder and then meets a fan of his. Addison suffers for her transgression, too, in the form of poison oak on her va-jay-jay.
When not performing bedside surgery on a little boy, Derek is trying to be Meredith's friend for once (especially when it looks like she might not have any other friends). Alex and Izzie get to treat Denny again -- but Izzie treats him much better. In addition to Denny, Burke has a male patient with a very delicate aneurism on his heart that can burst at any moment -- and knowing that leads the man's fiancée to leave him. Cristina and George are also on the case. After more self-pity from George, Cristina tells him to suck it up -- and George does -- he moves out. But only to wind up on Burke and Cristina's couch (much to her chagrin).

Band-Aid Covers the Bullet Hole
Meredith and Derek try being friends -- but she won't go far enough into the friendzone to tell him about George. Izzie and Alex both have talks with Denny. Alex tells him that he and Izzie are back together. Izzie convinces him that he needs to stay with her in the hospital. Cristina is stuck babysitting for Bailey's baby, and George and Callie further their flirtations over a teenaged patient who decides to chop off his own finger after Callie refuses to do it for him. Burke shows a preference for living with George over Cristina, and Addison gets a long-awaited admonition from Derek that shows some hope for their marriage after all.

Superstition
After four deaths in the morning, every doctors' personal superstitions and rituals come into focus. And the belief is that three more patients will die before the day is done. George continues to ignore Meredith -- but Callie seems to have lost patience with him as well, since he hasn't called her yet. Meredith and Bailey deal with a woman who claims to have been struck by lightning -- but clearly wasn't. Cristina has to deal with a patient with OCD who suffered a head trauma.
And Izzie and Alex turn their attention to a fading Denny -- each for their own reasons. Richard doesn't believe in any of the foolishness regarding surgical superstitions, but there's a ritual of his own he's been neglecting -- when his AA sponsor checks in with a serious condition, we learn that a) Richard is a recovered alcoholic and b) he hasn't been to a meeting in a while. As Izzie worries that Denny will be one of the seven, Alex is a little too blunt with him, and that results in their break-up, which leads Alex to blow up at George and then George to finally make a move with Callie.

The Name of the Game
Meredith takes up knitting -- and a vow of celibacy. Cristina competes with the Chief during classroom exercises. Burke tries to teach Alex a lesson about bedside manner, but it's a lesson that falls on deaf ears. Izzie knits, too, makes a sweater for Denny, and when she's not knitting, she's trying to get George to move back into the house and at the same time find out from Callie what her secret is (she seems to be hiding something, according to Izzie). George carries around the burden of discovering that Meredith's sister -- a sister she never knew she had -- is a patient of Addison's. And Bailey becomes Derek's intern for the day -- so she can get more OR time. Oh, and Meredith meets Doc's vet.

Blues For Sister Someone
Derek and Addison aren't having the best sex, something Meredith learns of by accident, just before Finn asks her out. Cristina works with Burke on one of his musical heroes. George and Izzie try to induce a seizure in patient, only to induce an argument over Meredith between them instead.
Addison and Alex have an expectant mother who wants her tubes secretly tied without her husband's knowledge  and Addison and Alex don't see eye-to-eye on the matter at all. Richard undermines Bailey's ability as a surgeon as she helps Denny get more mobile -- but not before Bailey begins to suspect that there is more to Denny and Izzie' relationship than just medicine. Meredith goes on that date with Finn -- to birth a horse. George returns home. And Derek finds a half-undressed Meredith at Finn's. Thinking they just had sex, he goes back to the trailer, ready to try again with Addison.

Damage Case
Derek is mad at Meredith. George is living back the house, though still not talking to Meredith. Cristina begins the day on a rush from just having been to a major surgery -- and sex to boot. But, though Burke involved in the latter, he's not entirely sharing Cristina's joy. In fact, they're last sexual encounter has left a bad taste in his mouth. Cristina doesn't notice, though, she's too excited about the incoming trauma cases: an exhausted surgical intern at another hospital falls asleep at the wheel of car and causes a three-car accident -- two of the cars contain members one big, loud Southern family -- and all of them need medical attention at SGH.
The injuries seem minor at first, until the glue of the family -- a pregnant young woman -- crashes during a routine CT. She's got devastating injuries. Just about every attending is on her case  including Addison and her new slave Alex. While Izzie spends more time worrying about the now mobile Denny (thanks to his portable LVAD), Alex is charged with merely watching the baby's vital signs during the course of a long, very invasive full body surgery -- a surgery that invokes an ominous occurrence known as the "triangle of death." But when the mother dies on the table, and her baby only has a few minutes left before it dies as well, Alex jumps into action and helps do an emergency C-section to save the baby's life -- and without Addison. George finally talks to Meredith, slowly tearing down that wall, but an even bigger wall is going up between Meredith and Derek -- he pretty much calls her a whore.

17 Seconds
A shooting a nearby restaurant bombards the hospital with plenty of gunshot victims -- and one intended victim that didn't get shot, but is a pain to everyone nonetheless. Burke is still mad at Cristina, and he lets Alex go with him to retrieve a heart and not her. Cristina winds up on the case of a couple where the boyfriend used his girlfriend as a shield during the shooting. When Izzie finds out that the heart is for Denny, she begs Bailey to be on the case, so she can tell Denny the good news and prep him. Meredith works with Callie on a victim who was shot in the leg. She uses the time with Callie to pick her brain about bone cancer in her dog, but Callie doesn't have time for any dog talk -- until George says he has a right to be mad at Meredith, but Callie doesn't. George and Derek attend to a victim left brain dead -- and pregnant.
Derek seeks Addison's help in talking to the parents about their decision to use their daughter as an incubator, but Addison -- who is seething to find out that Derek and Meredith's strife extends from her dating the Vet -- explodes on them, and then on Derek, in full view of everyone. When the heart intended for Denny doesn't prove to be viable, Burke fights for a second heart that is supposed to go another patient in another hospital -- and it's a battle he's losing until Izzie decides to take matters into her own hands. As Burke races back to SGH to keep Izzie from doing god-knows-what, both he and Denny wind up in critical situations.Finn gives a health update on Doc, Meredith is assigned to work with Callie for the day while George gets paired with Derek, and Burke and Izzie continue to try to find a heart for Denny.

Deterioration of the Fight or Flight Response
Burke has been shot and Izzie has just cut Denny's LVAD wire. George, Meredith, and Cristina all wind up helping Izzie keep Denny alive long enough to get moved up the transplant list and get the heart in question. Addison figures out that Richard's niece's (Camille) cancer has unfortunately returned. Bailey and Derek are attending to Burke -- and it's Derek who must operate on Burke to help save his surgical skills. Richard and his wife discuss his past affair with Ellis Grey. Meanwhile Alex desperately stalls at Mercy West in order to maintain possession of the donor heart while the rest of the interns struggle with each other in their fear of losing their places in the program&as well as Denny, who makes a surprise marriage proposal to Izzie amidst the madness.
After Bailey discovers the interns and Denny's situation, she helps them confirm Denny should receive the heart. Burke decides to have the surgery performed, risking nerve damage. But during his surgery, Derek must perform a wake-up test to check for nerve damage, and he asks Cristina for her help. But Cristina, horrified at the sight of Burke in pain on the table, freezes. Alex travels with Dr. Hahn from Mercy West with the heart, scrubbing in with Dr. Bailey for Denny's transplant. However, after the heart has been inserted, it still does not begin to beat&and back in Derek's OR, Burke still cannot move his fingers successfully.

Losing My Religion
Derek and Richard finish Burke's surgery as Denny successfully undergoes his heart transplant. Until one of them admits to cutting Denny's LVAD, the interns must attend to Richard's niece, which includes giving her a prom. As they each struggle with their own personal problems, they blow up balloons, hire catering, and decorate. As everyone works around him, Burke unfortunately finds a tremor in the movements of his right hand. Meredith and Derek sadly make the decision to put Doc to sleep. Richard continues to interrogate the interns, one by one, not receiving any direct answer about Denny's LVAD wire, only learning his interns' personal problems themselves. Izzie accepts Denny's marriage proposal. Meredith, Derek, Addison, and Finn finally put Doc to sleep as the hospital staff begins to arrive, dressed in full prom regalia.
As everyone dances and mingles, Meredith and Derek escape Finn and Addison to have a heated argument that only turns into a long awaited reunion. Meanwhile, alone in his room as Denny waits for Izzie, he experiences a sudden sense of pain, and he slowly closes his eyes... dying from an unexpected blood clot. Izzie runs to Denny's room to find only a code team, desperately hurrying in the same direction. One by one, the interns hurry to Denny's room to find a shocked Izzie, lying in bed next to his still form. As they each comfort her in any way they can, they all leave together and listen as Izzie confesses to Richard that she cut the LVAD wires. They only look on as they continue to listen to Izzie quit the program. After everyone begins going their separate ways, Meredith remains torn on who she should follow... Derek or Finn.